Fodor's Expert Review Maiden Lane

Known as Morton Street in the raffish Barbary Coast era, this former red-light district reported at least one murder a week during the late 19th century, though things cooled down after the 1906 fire. These days Maiden Lane is a chic, designer-boutique-lined pedestrian mall. Wrought-iron gates close the street to traffic most days between 11 and 5, when the lane becomes an alfresco hot spot dotted with umbrella-shaded tables. It's also popular with photographers and Instagrammers for its quaint-chic aesthetic. At 140 Maiden Lane is the only Frank Lloyd Wright building in San Francisco, fronted by a large brick archway. The curving ramp and skylights of the interior, which houses exclusive Italian menswear boutique Isaia, are said to have been his model for the Guggenheim Museum in New York.